轮状病毒是一种引起肠胃疾病的常见病毒，其临床危害性较大，具有分布广以及传染性高的特点，主要通过粪口传播，可感染小肠上皮细胞，造成细胞损伤，从而引起腹泻。婴幼儿感染轮状病毒引起腹泻后，易造成肠道菌群失调，同时降低T淋巴细胞的免疫活性，导致患儿免疫调节功能出现障碍。目前，临床上针对轮状病毒腹泻患儿的治疗主要以抗感染以及防脱水为主，虽可缓解患儿的脱水症状及腹泻症状，但由于轮状病毒种类较多，大部分患儿治疗后仍有机会受到感染，治疗效果尚不显著。锌是人体必需的微量元素，其在人体生长发育、生殖遗传、免疫、内分泌等重要生理过程中起着极其重要的作用。缺锌容易导致生长发育缓慢、消化及神经功能下降以及免疫系统遭到破坏等不良影响，因此给予轮状病毒腹泻患儿补锌可在一定程度上控制疾病。葡萄糖酸锌中的锌元素可以有效改善肠道菌群状态，修复因轮状病毒感染而损伤的肠道细胞，同时可促进肠道细胞的生长，从而提高患儿的抵抗力；锌存在于碳酸酐酶、乳酸脱氢酶以及DNA和RNA聚合酶等之中，能够促进蛋白质、核酸以及碳水化合物的合成，在提高患儿免疫功能上具有较强的促进作用；此外，锌能够刺激肠黏膜对水以及钠的吸收，控制水电解质的分泌，从而改善患儿的脱水症状。因此，对于轮状病毒腹泻患儿而言，葡萄糖酸锌是较为有效且安全性较高的治疗药物。

葡萄糖酸锌(Zinc Gluconate)治疗轮状病毒腹泻患儿的有效性

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甘氨酸亚铁Ferrous Glycinate、天门冬氨酸钙Calcium Aspartate、乳酸锌Zinc Lactate、葡萄糖酸锰Manganese Gluconate、甘氨酸镁Magnesium Glycinate、氨基酸螯合铬Chromium Amino Acid Chelate、谷氨酸锌Zinc Glutamate、苏氨酸镁Magnesium Threoninate、L-酪氨酸L-Tyrosine

The Effectiveness of Zinc Gluconate in Treating Children with Rotavirus Diarrhea

Rotavirus is a common virus that causes gastrointestinal diseases. It has great clinical harm, wide distribution and high infectivity. It is mainly transmitted through fecal mouth and can infect small intestinal epithelial cells, cause cell damage and cause diarrhea. After infantile infection with rotavirus caused diarrhea, it is easy to cause intestinal flora imbalance, and reduce the immune activity of T lymphocytes, resulting in immune regulation dysfunction in children. At present, clinical treatment for children with rotavirus diarrhea mainly focuses on anti-infection and anti-dehydration. Although the dehydration symptoms and diarrhea symptoms of children can be alleviated, most children still have the chance to be infected after treatment due to the large variety of rotavirus, and the therapeutic effect is not significant. Zinc is an essential trace element in human body, which plays an extremely important role in human growth and development, reproductive heredity, immunity, endocrine and other important physiological processes. Zinc deficiency is easy to lead to slow growth and development, digestive and nervous function decline and immune system damage and other adverse effects, so giving zinc supplementation to children with rotavirus diarrhea can control the disease to a certain extent. The zinc element in zinc gluconate can effectively improve the status of intestinal flora, repair intestinal cells damaged by rotavirus infection, and promote the growth of intestinal cells, thus improving the resistance of children. Zinc exists in carbonic anhydrase, lactate dehydrogenase and DNA and RNA polymerase, which can promote the synthesis of protein, nucleic acid and carbohydrate, and has a strong promoting effect on improving the immune function of children. In addition, zinc can stimulate the absorption of water and sodium by the intestinal mucosa and control the secretion of water and electrolytes, thereby improving the symptoms of dehydration in children. Therefore, zinc gluconate is an effective and safe treatment for children with rotavirus diarrhea.

The Effectiveness of Zinc Gluconate in Treating Children with Rotavirus Diarrhea

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