锌是公认的抗氧化剂与抗炎剂，在体内平衡、免疫功能、氧化应激、细胞凋亡和衰老中起着至关重要的作用。锌是人体必需的微量元素之一，其作为机体300多种酶的辅酶，参与机体DNA、RNA 及蛋白质的合成，可影响生物膜的稳定性和多蛋白复合物的排列，调节激素及其受体的形成，当机体缺锌，不仅影响免疫状态，增加氧化应激，还会导致炎症的发生。 锌可以影响许多炎症细胞因子的产生和信号传递，在体外可增强单核细胞对内皮细胞的黏附，并对促炎细胞因子的产生具有不利影响。缺锌会引起对脂多糖的过度炎症反应，加重多微生物脓毒血症小鼠的全身炎症反应和脓毒血症诱导的器官损伤易感性，增加肺组织中炎性细胞因子表达，这种炎性细胞因子的表达水平或与血清锌浓度呈现负相关趋势。锌缺乏除了导致炎性细胞因子分泌增多以外，还可加剧中性粒细胞迁移及上调趋化因子表达。从这些相似的研究结果可以看出，缺锌使宿主各种促炎细胞因子增加，加重炎症反应，而补充锌可在一定程度上逆转该过程。类似的，锌的加入可显著改善小鼠急性炎症反应，仔猪肠道感染，一定程度上可代替抗生素的使用，是临床抗炎剂的潜在候选者，前景广阔。

锌离子（甘氨酸锌Zinc Glycinate、L-天门冬氨酸锌Zinc Aspartate 、乳清酸锌Zinc Orotate、抗坏血酸锌Zinc Ascorbate、葡萄糖酸锌Zinc Gluconate、柠檬酸锌Zinc Citrate、苹果酸锌Zinc Malate、吡啶甲酸锌Zinc Picolinate）的抗炎作用机制

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甘氨酸钙Calcium Glycinate、葡萄糖酸锰Manganese Gluconate、富马酸亚铁Ferrous Fumarate、天门冬氨酸镁Magnesium Aspartate、氨基酸螯合铜Copper Amino Acid Chelate、赖氨酸镁Magnesium Lysinate、L-酪氨酸L-Tyrosine、L-半胱氨酸L-Cysteine、L-鸟氨酸盐酸盐L-Ornithine Hydrochloride、苹果酸钙Calcium Malate

Anti-inflammatory mechanism of zinc ion（Zinc Glycinate、Zinc Aspartate 、Zinc Orotate、Zinc Ascorbate、Zinc Gluconate、Zinc Citrate、Zinc Malate、Zinc Picolinate）

Zinc is a recognized antioxidant and anti-inflammatory agent that plays a vital role in homeostasis, immune function, oxidative stress, apoptosis and aging. Zinc is one of the essential trace elements in the human body. As a coenzyme of more than 300 enzymes in the body, it is involved in the synthesis of DNA, RNA and protein in the body, which can affect the stability of biofilm and the arrangement of multi-protein complexes, and regulate the formation of hormones and their receptors. When the body is deficient in zinc, it will not only affect the immune state, increase oxidative stress, but also lead to inflammation. Zinc can affect the production and signaling of many inflammatory cytokines, enhance the adhesion of monocytes to endothelial cells in vitro, and adversely affect the production of pro-inflammatory cytokines. Zinc deficiency can cause excessive inflammatory response to lipopolysaccharide, aggravate systemic inflammatory response and susceptibility to sepsis induced organ damage in mice with multimicrobial sepsis, and increase the expression of inflammatory cytokines in lung tissue, which may be negatively correlated with serum zinc concentration. In addition to the increased secretion of inflammatory cytokines, zinc deficiency can also increase neutrophil migration and up-regulate the expression of chemokines. From these similar results, it can be seen that zinc deficiency increases various proinflammatory cytokines in the host and aggravates the inflammatory response, and zinc supplementation can reverse this process to a certain extent. Similarly, the addition of zinc can significantly improve the acute inflammatory response of mice and intestinal infection of piglets, and can replace the use of antibiotics to a certain extent, which is a potential candidate for clinical anti-inflammatory agents with broad prospects.

Anti-inflammatory mechanism of zinc ion（Zinc Glycinate、Zinc Aspartate 、Zinc Orotate、Zinc Ascorbate、Zinc Gluconate、Zinc Citrate、Zinc Malate、Zinc Picolinate）

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Calcium Glycinate；Manganese Gluconate；Ferrous Fumarate；Magnesium Aspartate；Copper Amino Acid Chelate；Magnesium Lysinate；L-Tyrosine；L-Cysteine；L-Ornithine Hydrochloride；Calcium Malate