氨基酸螯合物是1个或多个氨基酸基团与可溶性的金属盐中的金属离子发生配合反应形成的具有环状结构的化合物。氨基酸螯合钙的吸收机理是以整个分子被肠粘膜细胞主动吸收，吸收入血后，以螯合物形式持续解离出Ca²⁺供机体利用，避免了血钙过高导致的肾排Ca²⁺ 量增加或高钙血症，保证了钙的充分吸收及利用。这种缓慢释放不引起机体调节稳定系统产生反射性抑制作用，属于不饱和吸收过程。有机酸钙产品的吸收率略高于无机钙产品，氨基酸螯合钙制剂的吸收率明显高于前两者。虽然氨基酸螯合钙的吸收机制明显的优于无机和传统有机酸钙制剂，但也不能证明其不具有潜在安全问题。吸收率高及不饱和吸收过程并不代表其长期服用对其他代谢途径、生理功能不产生负面影响，甚至具有致畸致突变的潜在安全隐患。然而人体对每种必需氨基酸的需求是有一定数量和比例要求的，人体若长期摄入组成比例不平衡的必需氨基酸，可能会使体内产生负氮平衡。不过迄今为止，还没有发现其具有急性毒性及致突变性。

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The effect of Amino acid chelate calcium on the human body

Amino acid chelates are compounds with ring structure formed by the reaction of one or more amino acid groups with metal ions in soluble metal salts. The absorption mechanism of amino acid chelated calcium is that the whole molecule is actively absorbed by intestinal mucosal cells, and after absorption into the blood, the Ca2+ is continuously dissociated in the form of chelate for the body to use, avoiding the increase of renal Ca2+ or hypercalcemia caused by excessive blood calcium, and ensuring the full absorption and utilization of calcium. This slow release does not cause reflective inhibition in the body's regulatory stability system, which belongs to the unsaturated absorption process. The absorption rate of organic calcium products was slightly higher than that of inorganic calcium products, and the absorption rate of amino acid chelated calcium preparations was significantly higher than the first two. Although the absorption mechanism of amino acid chelated calcium is clearly superior to inorganic and conventional organic calcium acid preparations, it does not prove that it does not have potential safety concerns. The high absorption rate and unsaturated absorption process do not mean that its long-term use will not have negative effects on other metabolic pathways and physiological functions, and even have potential safety hazards of teratogenicity and mutation. However, the human body needs a certain number and proportion of each essential amino acid, if the human body long-term intake of the proportion of essential amino acids is not balanced, it may cause the body to produce negative nitrogen balance. However, so far, no acute toxicity and mutagenicity have been found.

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