铜是人体内的关键微量元素，在维持人体生理动态平衡和抗菌方面起着至关重要的作用，与细胞免疫和体液免疫之间存在一定联系。铜离子常被报道具有良好的抗茵活性，其作为铜蓝蛋白的活性部位，通过刺激炎症细胞因子和低氧诱导因子的合成来促进铜蓝蛋白的合成和分泌。此外，在炎症、感染和其他疾病的急性期反应中，铜的代谢明显增强，以不同的氧化还原状态，使金属在细胞生理学中作为催化辅因子在酶的氧化还原化学、线粒体呼吸、铁吸收、自由基清除和弹性蛋白交联中发挥关键作用。铜掺入生物活性玻璃陶瓷构造含铜生物活性玻璃陶瓷支架可诱导巨噬细胞向抗炎表型极化，减少促炎细胞因子的分泌，显著促进软骨和骨软骨界面的再生，对于缺损组织的修复与再生具有有益影响，是潜在植入材料候选。释放的铜离子增加人细支气管上皮细胞分泌白细胞介素6、白细胞介素8和白细胞介素10等炎症细胞因子，使肿瘤坏死因子a的分泌显著减少，调节宿主炎症反应。

铜离子（甘氨酸铜Copper Glycinate、天门冬氨酸铜Copper Aspartate、氨基酸螯合铜Copper Amino Acid Chelate、柠檬酸铜Copper Citrate、葡萄糖酸铜Copper Gluconate）的抗炎作用作用

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L-谷氨酰胺L-Glutamine、L-异亮氨酸L-Isoleucine、L-色氨酸L-Tryptophan、甘氨酸钙Calcium Glycinate、抗坏血酸锌Zinc Ascorbate、吡啶甲酸锌Zinc Picolinate、柠檬酸钾Potassium Citrate、甘氨酸硼Boron Glycinate、氨基酸螯合硒Selenium Amino Acid Chelate、葡萄糖酸镁Magnesium Gluconate

Anti-inflammatory effect of Copper ions (Copper Glycinate, Copper Aspartate, Copper Amino Acid Chelate, Copper Citrate, Copper Gluconate)

Copper is a key trace element in human body, which plays a vital role in maintaining physiological homeostasis and antibacterial, and has a certain relationship with cellular immunity and humoral immunity. Copper ions have often been reported to have good anti-bacterial activity. As the active site of ceruloplasmin, copper ions promote the synthesis and secretion of ceruloplasmin by stimulating the synthesis of inflammatory cytokines and hypoxy-inducing factors. In addition, during the acute phase response of inflammation, infection, and other diseases, copper metabolism is significantly enhanced in different REDOX states, allowing the metal to play a key role in cellular physiology as a catalytic cofactor in enzyme REDOX chemistry, mitochondrial respiration, iron absorption, free radical clearance, and elastin crosslinking. The bioactive glass ceramic scaffold containing copper can induce the polarization of macrophages towards the anti-inflammatory phenotype, reduce the secretion of pro-inflammatory cytokines, and significantly promote the regeneration of cartilage and osteochondral interface, which has a beneficial effect on the repair and regeneration of defective tissues, and is a potential candidate for implantation materials. The release of copper ions increases the secretion of inflammatory cytokines such as interleukin 6, interleukin 8 and interleukin 10 by human bronchiolar epithelial cells, significantly reduces the secretion of tumor necrosis factor a, and regulates the host inflammatory response.

Anti-inflammatory effect of Copper ions (Copper Glycinate, Copper Aspartate, Copper Amino Acid Chelate, Copper Citrate, Copper Gluconate)

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L-Glutamine；L-Isoleucine；L-Tryptophan；Calcium Glycinate；Zinc Ascorbate；Zinc Picolinate；Potassium Citrate；Boron Glycinate；Selenium Amino Acid Chelate；Magnesium Gluconate；