在口腔护理领域中，自上世纪40年代首先发现含锌化合物具有抗牙菌斑的作用，能帮助防龋后，柠檬酸锌等化合物开始被加入牙膏中，帮助实现控制牙菌斑、缓解牙龈出血牙龈炎、抗牙结石等功能。按美国食品药品监督管理局对控制牙菌斑和缓解牙龈炎功效成分的分类，柠檬酸锌安全等级为Ⅰ，功效等级为Ⅲ，是牙膏中一种安全有效的功效成分。活性物柠檬酸锌，主要是介入牙菌斑生长的第二、三阶段，通过抑制口腔细菌的生长，减少牙菌斑的形成。锌化合物抗菌机理较多，主要有锌离子溶出抗菌学说、接触抗菌学说和纳米抗菌学说等。柠檬酸锌主要是以锌离子溶出抗菌学说为主，溶解的锌离子与细菌接触而产生抗菌作用。锌离子溶出抗菌可通过:(1) 破坏细胞膜功能;(2)使细菌蛋白质或酶类变性;(3)进入细菌细胞内的锌离子也可能与核酸结合，破坏细胞的分裂繁殖能力，达到抑菌和杀菌的目的。基于锌离子溶出抗菌学说，许多文献研究发现实际使用含柠檬酸锌牙膏后，口腔锌浓度很快就能提高，甚至能保留较长时间。临床研究发现使用牙膏提高口腔锌浓度的同时，能有效地抑制口腔细菌产生，能减少牙菌斑指数，并且减轻色素沉积。

柠檬酸锌（Zinc Citrate）对口腔细菌和牙菌斑的抑制作用

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牛磺酸镁Magnesium Taurate、氨基酸螯合钙Calcium Amino Acid Chelate、谷氨酸镁Magnesium Glutamate、赖氨酸锌Zinc Lysinate、L-异亮氨酸L-Isoleucine、甘氨酸铜Copper Glycinate、葡萄糖酸钾Potassium Gluconate、苹果酸钙Calcium Malate、抗坏血酸镁Magnesium Ascorbate、乳清酸镁Magnesium Orotate

Inhibitory effect of zinc citrate on oral bacteria and dental plaque

In the field of oral care, since the 1940s, it was first discovered that zinc-containing compounds have anti-plaque effects and can help prevent caries, zinc citrate and other compounds began to be added to toothpaste to help control dental plaque, relieve gingivitis, gingivitis and other functions. According to the U.S. Food and Drug Administration's classification of plaque control and gingivitis relief ingredients, zinc citrate safety level Ⅰ, efficacy level III, is a safe and effective ingredient in toothpaste. Zinc citrate, the active substance, mainly intervenes in the second and third stages of dental plaque growth, reduces the formation of dental plaque by inhibiting the growth of oral bacteria. There are many antibacterial mechanisms of zinc compounds, including the theory of zinc ion dissolution, contact and nano-antibacterial. Zinc citrate is mainly based on the antibacterial theory of zinc ion dissolution, and the antibacterial effect of dissolved zinc ion is produced by contact with bacteria. Zinc ion leaching can inhibit bacteria by :(1) destroying cell membrane function; (2) denaturation of bacterial proteins or enzymes; (3) Zinc ions entering bacterial cells may also combine with nucleic acids, destroy the cell's ability to divide and multiply, and achieve the purpose of bacteriostasis and sterilization. Based on the antibacterial theory of zinc ion dissolution, many literature studies have found that the oral zinc concentration can be increased quickly after the actual use of toothpaste containing zinc citrate, and even can be retained for a long time. Clinical studies have found that using toothpaste to increase oral zinc concentration can effectively inhibit the production of oral bacteria, reduce dental plaque index, and reduce pigmentation.

Inhibitory effect of zinc citrate on oral bacteria and dental plaque

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Magnesium Taurate、Calcium Amino Acid Chelate、Magnesium Glutamate、Zinc Lysinate、 L-Isoleucine、Copper Glycinate、Potassium Gluconate、Calcium Malate、Magnesium Ascorbate、Magnesium Orotate